Quick answer
- Federal
- Psilocybin and psilocin are Schedule I controlled substances
- Oregon
- Licensed service centers, age 21 and over, used on site only (ORS Chapter 475A)
- Colorado
- Licensed centers, plus personal possession and growing at 21 and over without payment
- On this site
- Information only; nothing containing psilocybin is listed or sold
Federal law
Psilocybin and psilocin, the compounds in psilocybin mushrooms, are Schedule I controlled substances under 21 U.S.C. 812 and 21 CFR 1308.11. State programs do not change that.
This page is information only. This site lists and sells nothing that contains psilocybin.
Oregon
Oregon voters approved the Oregon Psilocybin Services Act in November 2020. It is now Chapter 475A of the Oregon Revised Statutes, run by the Oregon Health Authority.
- Sessions on site. Under ORS 475A.355, an administration session must be held at a licensed psilocybin service center, with a licensed facilitator.
- Age 21. Sales to anyone under 21 are barred (ORS 475A.440).
- Nothing to take home. The Oregon Health Authority says products "may not be purchased and taken off-site."
- No prescription or residency. The Health Authority says neither is needed.
The Health Authority's 2025 year-end summary counts 377 licensed facilitators, 25 service centers, 11 manufacturers and 1 lab, and 5,935 clients served in 2025.
Colorado
Colorado voters approved the Natural Medicine Health Act in 2022, and the Legislature set out its rules in SB23-290, signed May 23, 2023. Two agencies run it: the Department of Revenue's Natural Medicine Division licenses businesses, and the Department of Regulatory Agencies licenses facilitators.
- Licensed centers. The first center license was issued March 31, 2025, and supervised sessions began at licensed centers in June 2025.
- Personal use at 21 and over. Adults may possess, use and share natural medicine without payment, and grow it for personal use in an enclosed, locked space of up to 12 by 12 feet. Selling it outside the licensed system is not allowed.
- Under 21 and in public. Possession under 21 and use in public are petty offenses.
As of October 30, 2026 the Natural Medicine Division listed 12 standard and 35 micro licensed centers, 15 cultivation facilities, 8 manufacturers and 1 testing facility.
Related pages
Mushroom spores by state covers the state laws on spores. Amanita muscaria covers a different mushroom with different law.
Common questions
Is psilocybin legal under federal law?
No. Psilocybin and psilocin are Schedule I controlled substances under 21 U.S.C. 812 and 21 CFR 1308.11. State programs in Oregon and Colorado do not change federal law.
How does Oregon's psilocybin program work?
Under ORS Chapter 475A, adults 21 and older may take psilocybin in an administration session at a licensed psilocybin service center, with a licensed facilitator. The Oregon Health Authority says no prescription or Oregon residency is needed and products may not be bought and taken off site.
What does Colorado's Natural Medicine Health Act allow?
Adults 21 and older may possess, use, share without payment, and grow natural medicine for personal use, with limits on growing space. Licensed centers offer supervised sessions. The Department of Revenue licenses businesses and the Department of Regulatory Agencies licenses facilitators.
Sources
- 21 U.S.C. 812, schedules of controlled substances, GovInfo, U.S. Government Publishing Office
- 21 CFR 1308.11, Schedule I, eCFR, National Archives
- ORS Chapter 475A, psilocybin, Oregon State Legislature
- Accessing psilocybin services, Oregon Health Authority
- Oregon Psilocybin Services, 2025 year-end data summary, Oregon Health Authority
- SB23-290, Natural Medicine Regulation and Legalization, Colorado General Assembly
- Natural Medicine Division, Colorado Department of Revenue
- Natural Medicine frequently asked questions, Colorado Department of Revenue
- Colorado Natural Medicine Program, Colorado Department of Regulatory Agencies
Each source was last read on November 5, 2026. Laws and rules change; check the source for the current text.